R-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID (RCMH)

R-(-)-3-(Carbamoylmethyl)-5-methylhexanoic acid (RCMH) is the (R)-enantiomer of 3-(carbamoylmethyl)-5-methylhexanoic acid, a chiral intermediate related to the synthesis of Pregabalin, a drug used to treat epilepsy, neuropathic pain, and anxiety. Unlike the (S)-enantiomer, which is the pharmacologically active form used in Pregabalin, the R-enantiomer (RCMH) is inactive in terms of therapeutic effect. However, it plays a crucial role in chiral separation processes during the manufacturing of Pregabalin. The presence and control of RCMH in the final product are strictly regulated, as excessive amounts can affect the drug's purity and efficacy. Accurate identification and quantification of RCMH are essential in quality control, especially in accordance with pharmacopeial standards such as USP, EP, or BP. Though not used directly as a drug or intermediate for active medications, RCMH must be effectively separated or minimized during the enantiomeric resolution process to ensure a safe and effective Pregabalin product.